David Canning, PhD, and alumni Natalie Brelsford and Neil Lovett, are this week’s #RacerScholars!

Professor canningDavid R. Canning and two alumni, Natalie R. Brelsford ’14 and Neil W. Lovett ’14, are this week’s #RacerScholars. The two students contributed to the article, “Chondroitin sulfate effects on neural stem cell differentiation,” with Dr. Canning.

This article was published in volume 52, issue 1 of In Vitro Cellular & Developmental Biology – Animal.


We have investigated the role chondroitin sulfate has on cell interactions during neural plate formation in the early chick embryo. Using tissue culture isolates from the prospective neural plate, we have measured neural gene expression profiles associated with neural stem cell differentiation. Removal of chondroitin sulfate from stage 4 neural plate tissue leads to altered associations of N-cadherin-positive neural progenitors and causes changes in the normal sequence of neural marker gene expression. Absence of chondroitin sulfate in the neural plate leads to reduced Sox2 expression and is accompanied by an increase in the expression of anterior markers of neural regionalization. Results obtained in this study suggest that the presence of chondroitin sulfate in the anterior chick embryo is instrumental in maintaining cells in the neural precursor state.

Chondroitin sulfate effects on neural stem
cell differentiation

By David Canning, Natalie R Brelsford,
and Neil Lovett
In Vitro Cellular & Developmental Biology – Animal.:
JAN 2016, vol. 52(1), pgs. 35-44
DOI: 10.1007/s11626-015-9941-8


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